Inj. Moxaclav 1 gm + 200 mg information and price in Bangladesh

Information: Inj. Moxaclav 1 gm + 200 mg

Therapeutic action – Combination of two antibacterials. The addition of clavulanic acid to amoxicillin extends its spectrum of activity to cover beta-lactamase producing Gram-positive and Gram-negative organisms, including some Gram-negative anaerobes. Indications – Animal bites, if antibiotic therapy or antibiotic prophylaxis is clearly indicated – Second line treatment of acute otitis media and acute bacterial sinusitis, when amoxicillin alone given at high dose failed – Acute uncomplicated cystitis (no systemic signs) in girls > 2 years – Postpartum upper genital tract infection – Severe pneumonia: parenteral to oral switch therapy in patients treated with ceftriaxone + cloxacillin Presentation – The ratio of amoxicillin and clavulanic acid varies according to the manufacturer: Ratio 8:1 – 500 mg amoxicillin/62.5 mg clavulanic acid tablet – 500 mg amoxicillin/62.5 mg clavulanic acid/5 ml powder for oral suspension Ratio 7:1 – 875 mg amoxicillin/125 mg clavulanic acid tablet – 400 mg amoxicillin/57 mg clavulanic acid/5 ml, powder for oral suspension Ratio 4:1 – 500 mg amoxicillin/125 mg clavulanic acid tablet – 125 mg amoxicillin/31.25 mg clavulanic acid/5 ml, powder for oral suspension Also comes in formultions with a ratio amoxicillin/clavulanic acid of 16:1, 14:1, 6:1, 2:1. Dosage (expressed in amoxicillin) – Animal bites; second line treatment of acute otitis media and acute sinusitis • Child < 40 kg: 45 to 50 mg/kg/day in 2 divided doses (if using ratio 8:1 or 7:1) or in 3 divided doses (if using ratio 4:1) Note: the dose of clavulanic acid should not exceed 12.5 mg/kg/day or 375 mg/day. • Child ≥ 40 kg and adult: 1500 to 2000 mg/day depending on the formulation available: Ratio 8:1: 2000 mg/day = 2 tablets of 500/62.5 mg 2 times per day Ratio 7:1: 1750 mg/day = 1 tablet of 875/125 mg 2 times per day Ratio 4:1: 1500 mg/day = 1 tablet of 500/125 mg 3 times per day Note: the dose of clavulanic acid should not exceed 375 mg/day. – Acute uncomplicated cystitis in girls > 2 years 25 mg/kg/day in 2 divided doses (if using ratio 8:1 or 7:1 or 4:1) Note: the dose of clavulanic acid should not exceed 12.5 mg/kg/day or 375 mg/day. – Postpartum upper genital tract infection; parenteral to oral switch therapy in severe pneumonia Use formulations with a ratio 8:1 or 7:1: • Child < 40 kg: 80 to 100 mg/kg/day in 2 or 3 divided doses Note: the dose of clavulanic acid should not exceed 12.5 mg/kg/day or 375 mg/day. • Child ≥ 40 kg and adult: 2500 to 3000 mg/day in 3 divided doses. Depending on the formulation available: Ratio 8:1: 3000 mg/day = 2 tablets of 500/62.5 mg 3 times per day Ratio 7:1: 2625 mg/day = 1 tablet of 875/125 mg 3 times per day Note: the dose of clavulanic acid should not exceed 375 mg/day. Duration – Animal bites: 5 to 7 days; otitis media: 5 days; sinusitis: 7 to 10 days; cystitis: 3 days; upper genital tract infection: 7 days; parenteral to oral switch therapy in severe pneunonia: to complete a total of 10 to 14 days of treatment. Contra-indications, adverse effects, precautions – Do not administer to penicillin-allergic patients and patients with history of hepatic disorders during a previous treatment with co-amoxiclav. – Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur). – Administer with caution to patients with hepatic impairment; reduce dosage and give every 12 to 24 hours in patients with severe renal impairment. – May cause: gastrointestinal disturbances (mainly diarrhoea); allergic reactions sometimes severe (stop treatment immediately); jaundice and cholestatic hepatitis in the event of prolonged treatment (> 10 to 15 days). – Pregnancy: no contra-indication – Breast-feeding: no contra-indication Remarks – High doses of co-amoxiclav (80-100 mg/kg/day or 2.5-3 g/day) cannot be administered when using formulations of amoxicillin/clavulanic acid in a ratio of 4:1 (the content in clavulanic acid is too high). The maximum dose (expressed in amoxicillin) that can be given with these formulations is 50 mg/kg/day, without exceeding 1500 mg/day. – Take with meals. – Storage: below 25°C – – Powder for oral suspension: between 15°C and 25°C Once reconstituted, the oral suspension must be kept refrigerated (between 2°C and 8°C) and may be used for up to 7 days. https://www.squarepharma.com.bd/product-details.php?pid=237 https://medlineplus.gov/druginfo/meds/a685024.html https://en.wikipedia.org/wiki/Amoxicillin

Caution: Inj. Moxaclav 1 gm + 200 mg

Before taking Inj. Moxaclav 1 gm + 200 mg, inform your doctor if you or your child have liver or kidney problems or any allergies. It should be used with caution in patients with liver problems due to alcohol to prevent the risk of liver damage.

Inj. Moxaclav 1 gm + 200 mg should be used with caution in pregnant women only if clearly advised by the doctor and can be used in breastfeeding women.

Inj. Moxaclav 1 gm + 200 mg is not recommended for use in children less than 10 years of age and should be used with caution in elderly patients.

Consult your doctor if you experience any side effects or unusual effects during treatment with Inj. Moxaclav 1 gm + 200 mg.

Safety: Inj. Moxaclav 1 gm + 200 mg

It is unsafe to consume alcohol with Inj. Moxaclav 1 gm + 200 mg